VP tends to be a pick to offset weaknesses / complement the President. Usually more important for campaigning than once in office. For example, Biden was tapped as VP because he has foreign policy experience and seniority to Obama’s lack thereof. Bush tapped Cheney because he needed a puppet master–'ya understand.

For Biden, AOC may pull progressives in more, but I suspect they’d rather appeal to black voters in all frankness.

I’ll say that if AOC has presidential ambitions, and I hope she does, then being VP is a great way to rapidly gain experience.